Характеристика гена ингибитора активатора плазминогена 1 типа (PAI-1) и его роль в развитии артериального тромбоза
Ингибитор активатора плазминогена-1 (PAI-1) является основным физиологическим ингибитором фибринолитической системы in vivo. Результаты современных исследований не позволяют сформировать однозначное мнение о степени влияния уровня PAI-1 и его полиморфизма (4G/5G, 4G/4G) на частоту развития тромботических событий в артериальном русле. В связи с этим целью данного обзора является составление обобщающей характеристики свойств PAI-1, а также установление роли его полиморфизма в развитии тромбоза в зависимости от индивидуальных физиологических и этнических факторов, а также перспективных направлений в его дальнейшем изучении.Изможерова Н.В., Попов А.А., Антропова И.П., Кадников Л.И., Полянок А.О., Испавский В.Е.
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Список литературы
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Об авторах / Для корреспонденции
Автор для связи: Леонид Игоревич Кадников, аспирант кафедры фармакологии и клинической фармакологии, Уральский государственный медицинский университет, Екатеринбург, Россия; kadn-leonid@mail.ru
ORCID:
Н.В. Изможерова (N.V. Izmozherova), https://orcid.org/0000-0001-7826-9657
А.А. Попов (A.A. Popov), https://orcid.org/0000-0001-6216-2468
И.П. Антропова (I.P. Antropova), https://orcid.org/0000-0002-9957-2505
Л.И. Кадников (L.I. Kadnikov), https://orcid.org/0000-0002-2623-2657
А.О. Полянок (A.O. Polyanok), https://orcid.org/0000-0003-1300-8768
В.Е. Испавский (V.E. Ispavsky), https://orcid.org/0000-0001-8152-6474