Легочная сенесценция (старение): дискуссионные вопросы
В наши дни происходит стремительный рост числа пациентов пожилого возраста, требующий значительного расширения наших представлений об основах «биологии старения», или сенесценции. Легочная система состоит из уникального набора клеток различного типа, которые на протяжении всей человеческой жизни подвергаются постоянному химическому, механическому, биологическому, иммунологическому, ксенобиотическому стрессам. До настоящего времени остаются малопонятными механизмы сенесценции легких, причины увеличения рисков паренхиматозных легочных заболеваний, смертельных респираторных инфекций, первичного рака легких среди пациентов старшей возрастной группы. В настоящем обзоре мы постарались представить в форме научного обзора с дискуссией молекулярные и клеточные механизмы старения легкого, особенно предрасполагающие к развитию легочных заболеваний.Бабак С.Л., Горбунова М.В., Карнаушкина К.М.
Ключевые слова
биологии старения
легочная сенесценция
ксенобиотический стресс
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Об авторах / Для корреспонденции
Автор для связи: Сергей Львович Бабак, врач-пульмонолог, д.м.н., доцент, профессор кафедры фтизиатрии и пульмонологии НОИ клинической медицины им. Н.А. Семашко, Российский университет медицины, Москва, Россия; sergbabak@mail.ru
ORCID / Scopus Author ID / eLibrary SPIN:
С.Л. Бабак (S.L. Babak), ORCID: https://orcid.org/0000-0002-6571-1220; Scopus Author ID: 45560913500; eLibrary SPIN: 5213-3620; Web of Science ResearcherID: KAO-3183-2024
М.В. Горбунова (M.V. Gorbunova), ORCID: https://orcid.org/0000-0002-2039-0072; Scopus Author ID: 45561369300
М.А. Карнаушкина (K.M. Karnaushkina), ORCID: https://orcid.org/0000-0002-8791-2920; Scopus Author ID: 7801543452; eLibrary SPIN: 3297-8985
