ISSN 2073–4034
eISSN 2414–9128

Бензодиазепины: классификация, свойства, количественное определение и мониторинг

Кузьмин И.И., Кравцова О.Ю., Платова А.И., Мирошниченко И.И.

1) Научный центр психического здоровья, Москва, Россия; 2) НИИ фармакологии им. В.В. Закусова, Москва, Россия
В обзорной статье описаны общие характеристики и классификация бензодиазепинов (БЗД), методы количественного определения и область их применения. Разобраны воздействие БЗД на рецепторы γ-аминомасляной кислоты и вопросы безопасности их применения. Приводятся сведения по фармакологии, метаболизму и фармакогенетике БЗД. Представлены скрининговые и количественные способы определения БЗД, включая методы экстракции. В сравнительном аспекте описаны основные методы количественного определения БЗД: иммуноферментный анализ и высокоэффективная жидкостная хроматография с масс-спектрометрией.

Ключевые слова

бензодиазепины
параметры кинетики
хроматография
масс-спектрометрическое детектирование

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Об авторах / Для корреспонденции

Автор для связи: Игорь Иванович Мирошниченко, д.м.н., зав. лаборатории фармакокинетики, Научный центр психического здоровья, Москва, Россия; igormir@psychiatry.ru 

ORCID / SPIN-код:
И.И. Мирошниченко (I.I. Miroshnichenko), https://orcid.org/0000-0003-4950-5336; SPIN-код: 4117-9703
И.И. Кузьмин (I.I. Kuzmin), https://orcid.org/0000-0002-9326-4683; SPIN-код: 1442-0325
О.Ю. Кравцова (O.Yu. Kravtsova), https://orcid.org/0000-0002-0693-2007; SPIN-код: 1733-2330
А.И. Платова (A.I. Platova), https://orcid.org/0000-0002-9682-4623; SPIN-код: 6656-2194

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