Фенотипы синдрома поликистозных яичников
Синдром поликистозных яичников (СПКЯ) является наиболее распространенным эндокринным заболеванием у женщин репродуктивного возраста, при этом до 70% случаев остаются недиагностированными в результате значительной клинической гетерогенности. Данный обзор подробно описывает диагностические критерии СПКЯ, разбирает существующие фенотипы заболевания, а также описывает этиопатогенетическое значение инсулинорезистентности (ИР) в развитии гиперандрогении и репродуктивных нарушений. Для выбора лечебной тактики подчеркивается важность не только точной диагностики СПКЯ, но и определения клинического фенотипа заболевания с детальным анализом морфологической структуры яичников и дополнительным исследованием метаболических параметров, таких как масса тела и индекс ИР. Обоснован дифференцированный подход к назначению инсулинсенситайзеров при различных фенотипах СПКЯ.Пустотина О.А.
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Список литературы
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Об авторах / Для корреспонденции
Автор для связи: Ольга Анатольевна Пустотина, д.м.н., профессор кафедры акушерства и гинекологии с курсом репродуктивной медицины, Академия медицинского образования им. Ф.И. Иноземцева, Санкт-Петербург, Россия; pustotina@gmail.com; ORCID: https://orcid.org/0000-0001-6117-7270