Клиническая фармакология ингибиторов натрий-глюкозного котранспортера-2
Представлен обзор по клинической фармакологии нового класса пероральных сахароснижающих препаратов – ингибиторов натрий-глюкозного котранспортера-2 (иНГЛТ-2, или глифлозинов). Описан основной механизм действия иНГЛТ-2, а также других метаболических, сердечно-сосудистых, почечных эффектов, которые относятся к плейотропным класс-эффектам. Представлены данные по фармакодинамике, фармакокинетике препаратов (дапаглифлозин, канкглифлозин, эмпаглифлозин, эртуглифлозин, ипраглифлозин, лусеоглифлозин, сотаглифлозин); побочные эффекты и лекарственные взаимодействия. Данные по клинической фармакологии класса иНГЛТ-2 будут способствовать лучшему пониманию основного механизма действия и плейотропных эффектов, обеспечивающих кардиопротекторное и ренопротекторное действия.Леонова М.В.
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Список литературы
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