Проблемы трансплантации поджелудочной железы и роль биоинженерных материалов в долгосрочной выживаемости и функционировании островковых клеток
Замена β-клеток с помощью трансплантации донорской поджелудочной железы (ПЖ) или клеточной терапии может быть решением ряда проблем, связанных с лечением пациентов с сахарным диабетом 1 типа. В статье обсуждаются проблемы трансплантации ПЖ и островковых клеток, роль внеклеточного матрикса в поддержании функциональной активности и выживании β-клеток островков ПЖ. Представлены данные о возможных источниках инсулин-продуцирующих клеток и эволюции методов трансплантации. В статье обсуждаются особенности биоматериалов для биоинженерных каркасов, направленных на защиту трансплантата от иммунных реакций реципиента, облегчение обмена жизненно важными молекулами, улучшение жизнеспособности и метаболической активности островковых клеток. Проведен анализ преимуществ и недостатков инкапсулирующих устройств различного размера, возможных решений вопроса васкуляризации трансплантата, а также перспектив применения 3D-биопечати ПЖ.Булгакова С.В., Шаронова Л.А., Долгих Ю.А., Косарева О.В., Тренева Е.В., Курмаев Д.П.
Ключевые слова
сахарный диабет
трансплантация поджелудочной железы
клеточная терапия
биоинженерия
биоинженерные каркасы
гидрогели
биопринтинг
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73. Польские учёные напечатали первую в мире бионическую поджелудочную железу с сосудами / Хабр
74. Academia and business to develop 3D printed pancreas for testing diabetes medication - Med-Tech Innovation.
Об авторах / Для корреспонденции
Автор для связи: Людмила Александровна Шаронова, к.м.н., доцент кафедры эндокринологии и гериатрии, Самарский государственный медицинский университет, Самара, Россия; l.a.sharonova@samsmu.ru
ORCID:
Булгакова С.В. (Svetlana V. Bulgakova), https://orcid.org/0000-0003-0027-1786
Шаронова Л.А. (Lyudmila A. Sharonova), https://orcid.org/0000-0001-8827-4919
Долгих Ю.А. (Yuliya A. Dolgikh), https://orcid.org/0000-0001-6678-6411
Косарева О.В. (Olga V. Kosareva), https://orcid.org/0000-0002-5754-1057
Тренева Е.В. (Ekaterina V. Treneva), https://orcid.org/0000-0003-0097-7252
Курмаев Д.П. (Dmitry P. Kurmaev), https://orcid.org/0000-0003-4114-5233
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