ISSN 2073–4034
eISSN 2414–9128

Рубцовые алопеции: классификация, клинико-морфологические особенности, диагностика и лечение (обзор литературы)

Раводин Р.А., Круглова Л.С., Денисова Е.А.

1) Центральная государственная медицинская академия УДП РФ, Москва, Россия; 2) Северо-Западный государственный медицинский университет им. И.И. Мечникова, Санкт-Петербург, Россия; 3) Клиника Волосы.ру, Санкт-Петербург, Россия
До 8% дерматологических пациентов обращаются к врачам по поводу выпадения волос. Из причин, вызывающих выпадение волос, рубцовая алопеция (РА) представляет собой сложную диагностическую и терапевтическую проблему. РА включает группу заболеваний, при которых общим конечным итогом является разрушение волосяного фолликула, который замещается соединительной тканью. Необратимость выпадения волос и связанные с этим неблагоприятные косметические последствия РА требуют особого внимания к их своевременной диагностике. Различают первичные и вторичные РА. Первичные РА характеризуются фолликулоцентрическим воспалительным процессом, который приводит к разрушению волосяного фолликула, при вторичных РА волосяной фолликул поражается опосредованно вместе с другими структурами кожи. На долю первичных РА, которые представляют наибольшую трудность в диагностическом и терапевтическом планах, приходится 3–7%. Диагностика заболевания, вызвавшего первичную РА, основывается на тщательном сборе анамнеза пациента, клиническом обследовании, дерматоскопических (трихоскопических) данных и результатах биопсии кожи волосистой части головы, что является необходимым условием для назначения соответствующей терапии. В статье представлены данные литературы, посвященные вопросам классификации, диагностики и лечения различных видов РА.

Ключевые слова

рубцовые алопеции
первичные рубцовые алопеции
вторичные рубцовые алопеции
трихоскопия
биопсия
лечение
трансплантация волос

Список литературы

1. Мильдзихова Д.Р., Мельниченко О.О., Корсунская И.М. Современные подходы к терапии андрогенетической алопеции. Клиническая дерматология и венерология. 2019;18(4):501–4.

2. Trüeb R.M. Vernarbende Alopezien

3. Pradhan P., D’Souza M., Bade B.A., et al. Psychosocial impact of cicatricial alopecias. Indian J Dermatol. 2011;56(6):684–88. Doi: 10.4103/0019-5154.91829.

4. Ross E.K., Tan E., Shapiro J. Update on primary cicatricial alopecias. J Am Acad Dermatol. 2005;53(1):1–37; quiz 38–40. Doi: 10.1016/j.jaad.2004.06.015. Erratum in: J Am Acad Dermatol. 2005;53(3):496.

5. Whiting D.A. Cicatricial alopecia: clinico-pathological findings and treatment. Clin Dermatol. 2001;19(2):211–25. Doi: 10.1016/s0738-081x(00)00132-2.

6. Rongioletti F., Christana K. Cicatricial (Scarring) Alopecias. Am J Clin. Dermatol. 2012;13(4):247–60. Doi: 10.2165/11596960-000000000-00000.

7. Somani N., Bergfeld W.F. Cicatricial alopecia: classification and histopathology. Dermatol Ther. 2008;21:221–37.

8. Sperling L.C., Cowper S.E. The histopathology of primary cicatricial alopecia. Semin Cutan Med Surg. 2006;25:41–50.

9. Harries M.J., Trueb R.M., Tosti A., et al. How not to get scar(r)ed: pointers to the correct diagnosis in patients with suspected primary cicatricial alopecia. Br J Dermatol 2009;160:482–501.

10. Stefanato C.M. Histopathologic diagnosis of alopecia: clues and pitfalls in the follicular microcosmos. Diagnostic Histopathol. 2020;26(3):114–27. Doi: 10.1016/j.mpdhp.2019.12.003.

11. McElwee K.J. Etiology of cicatricial alopecias: a basic science point of view. Dermatol Ther. 2008;21:212–20.

12. Trachsler S., Trueb R.M. Value of direct immunofluorescence for differential diagnosis of cicatricial alopecia. Dermatol. 2005;211(2):98–102. Doi: 10.1159/000086436.

13. Olsen E.A., Bergfeld W.F., Cotsarelis G., et al. Workshop on Cicatricial Alopecia. Summary of North American Hair Research Society (NAHRS)-sponsored Workshop on Cicatricial Alopecia, Duke University Medical Center, February 10 and 11, 2001. J Am Acad Dermatol. 2003;48(1):103–10. Doi: 10.1067/mjd.2003.68.

14. McElwee KJ. Etiology of cicatricial alopecias: a basic science point of view. Dermatol Ther. 2008;21(4):212–20. Doi: 10.1111/j.1529-8019.2008.00202.x.

15. Harries M.J., Meyer K.C., Chaudhry I.H., et al. R. Does collapse of immune privilege in the hair-follicle bulge play a role in the pathogenesis of primary cicatricial alopecia? Clin Exp Dermatol. 2010;35(6):637–44. Doi: 10.1111/j.1365-2230.2009.03692.x.

16. Hoang M.P., Keady M., Mahalingam M. Stem cell markers (cytokeratin 15, CD34 and nestin) in primary scarring and nonscarring alopecia. Br J Dermatol. 2009;160(3):609–15. Doi: 10.1111/j.1365-2133.2008.09015.x.

17. Karnik P., Tekeste Z., McCormick T.S., et al. Hair follicle stem cell-specific PPARgamma deletion causes scarring alopecia. J Invest Dermatol. 2009;129(5):1243–57. Doi: 10.1038/jid.2008.369..

18. Harries M.J., Paus R. Scarring alopecia and the PPAR-gamma connection. J Invest Dermatol. 2009;129(5):1066–70. Doi: 10.1038/jid.2008.425.

19. Harries M.J., Paus R. The pathogenesis of primary cicatricial alopecias. Am J Pathol. 2010;177(5):2152–62. Doi: 10.2353/ajpath.2010.100454.

20. Rosenblum M.D., Yancey K.B., Olasz E.B., Truitt R.L. CD200, a «no danger» signal for hair follicles. J Dermatol Sci. 2006;41(3):165–74. Doi: 10.1016/j.jdermsci.2005.11.003.

21. Rigopoulos D., Stamatios G., Ioannides D. Primary Scarring Alopecias. Curr Probl Dermatol. 2015:47:76–86. Doi: 10.1159/000369407.

22. Rongioletti F., De Lucchi S., Meyes D., et al. Follicular mucinosis: a clinicopathologic, histochemical, immunohistochemical and molecular study comparing the primary benign form and the mycosis fungoides associated follicular mucinosis. J Cutan Pathol. 2010;37:15–9.

23. Romine K.A., Rothschild J.G., Hansen R.C. Cicatricial alopecia and keratosis pilaris: keratosis follicularis spinulosa decalvans. Arch Dermatol. 1997;133:381–84.

24. Bhoyrul B. A simple technique to distinguish fibrosing alopecia in a pattern distribution from androgenetic alopecia and concomitant seborrheic dermatitis. J Am Acad Dermatol. 2022;86(1):163–65. Doi: 10.1016/j.jaad.2020.12.077.

25. Lacarrubba F., Micali G., Tosti A. Scalp dermoscopy or trichoscopy. Curr Probl Dermatol. 2015;47:21–32. Doi: 10.1159/000369402.

26. Stefanato C.M. Histopathology of alopecia: a clinicopathological approach to diagnosis. Histopathol. 2010;56(1):24–38. Doi: 10.1111/j.1365-2559.2009.03439.x.

27. Doche I., Romiti R., Hordinsky M.K., Valente N.S. «Normal-appearing» scalp areas are also affected in lichen planopilaris and frontal fibrosing alopecia: An observational histopathologic study of 40 patients. Exp Dermatol. 2020;29(3):278–81. Doi: 10.1111/exd.13834.

28. Miteva M., Tosti A. Dermoscopy guided scalp biopsy in cicatricial alopecia. J Eur. Acad Dermatol Venereol. 2013;27:1299–303.

29. Rakowska A., Slowinska M., KowalskaOledzka E., et al. Trichoscopy of cicatricial alopecia. J Drugs Dermatol. 2012;11:753–58.

30. Nguyen J.V., Hudacek K., Whitten J.A., et al. The HoVert technique: a novel method for the sectioning of alopecia biopsies. J Cutan Pathol. 2011;38:401.

31. Kolivras A., Thompson C. Primary scalp alopecia: new histopathological tools, new concepts and a practical guide to diagnosis. J Cutan Pathol. 2016;44(1):53–69. Doi: 10.1111/cup.12822.

32. Zinkernagel M.S., Med C., Trueb R.M. Fibrosing alopecia in a pattern distribution. Arch Dermatol. 2000;136:205–11.

33. Starace M., Orlando G., Alessandrini A., et al. Diffuse variants of scalp lichen planopilaris: clinical, trichoscopic, and histopathologic features of 40 patients. J.Am. Acad. Dermatol. 2020;83:1659–67.

34. Saceda‐Corralo D., Fernandez‐Crehuet P., Fonda‐Pascual .P, et al. Clinical description of frontal fibrosing alopecia with concomitant lichen planopilaris. Skin Appendage Disord. 2018;4:105–7.

35. Meinhard J., Stroux A., Lunnemann L., et al. Lichen planopilaris: epidemiology and prevalence of subtypes – a retrospective analysis in 104 patients. JDDG. 2014;12:229–35.

36. Bolduc C., Sperling L.C., Shapiro J. Primary cicatricial alopecia: Lymphocytic primary cicatricial alopecias, including chronic cutaneous lupus erythematosus, lichen planopilaris, frontal fibrosing alopecia, and Graham-Little syndrome. J Am Acad Dermatol. 2016;75(6):1081–99. Doi: 10.1016/j.jaad.2014.09.058.

37. Svigos K., Yin L., Fried L., et al. A practical approach to the diagnosis and management of classic lichen planopilaris. Am J Clin Dermatol. 2021;22:681–92.

38. Navarini A.A. Low‐dose excimer 308‐nm laser for treatment of lichen planopilaris. Arch Dermatol. 2011;147:1325–26.

39. Yang C.C., Khanna T., Sallee B., et al. Tofacitinib for the treatment of lichen planopilaris: a case series. Dermatol Ther. 2018;31:e12656.

40. Lee B., Elston D.M. The uses of naltrexone in dermatologic conditions. J Am Acad Dermatol. 2019;80:1746–52.

41. Strazzulla L.C., Avila L., lo Sicco K., Shapiro J. Novel treatment using low-dose naltrexone for lichen planopilaris. J Drugs Dermatol. 2017;16:1140–2.

42. Tziotzios C., Stefanato C.M., Fenton D.A., et al. Frontal fibrosing alopecia: reflections and hypotheses on aetiology and pathogenesis. Exp Dermatol. 2016;25(11):847–52. Doi: 10.1111/exd.13071.

43. Photiou L., Nixon R.L., Tam M., et al. An update of the pathogenesis of frontal fibrosing alopecia: What does the current evidence tell us? Australas. J Dermatol. 2018;60(2). Doi: 10.1111/ajd.12945.

44. Robinson G., McMichael A., Wang S.Q., et al. Sunscreen and Frontal Fibrosing Alopecia: A Review. J Am Acad Dermatol. 2019;82(3). Doi: 10.1016/j.jaad.2019.09.085.

45. Pirmez R., Duque‐Estrada B., Abraham L.S., et al. It’s not all traction: the pseudo ‘fringe sign’ in frontal fibrosing alopecia. Br J Dermatol. 2015;173:1336–38.

46. Moreno-Arrones O.M., Saceda-Corralo D., Fonda-Pascual P., et al. Frontal fibrosing alopecia: clinical and prognostic classification. J Eur Acad Dermatol. Venereol. 2017;31:1739–45.

47. Starace M., Orlando G., Iorizzo M., et al. Clinical and Dermoscopic Approaches to Diagnosis of Frontal Fibrosing Alopecia: Results From a Multicenter Study of the International Dermoscopy Society. Dermatol Pract Concept. 2022;12(1):e2022080. Doi: 10.5826/dpc.1201a80.

48. Kepinska K., Jałowska M., Bowszyc-Dmochowska M. Frontal Fibrosing Alopecia – a review and a practical guide for clinicians. Ann Agric Environ Med. 2022;29(2):169–84. Doi: 10.26444/aaem/141324.

49. Vano-Galvan S., Molina-Ruiz A.M., Serrano-Falcon C., et al. Frontal fibrosing alopecia: a multicenter review of 355 patients. J Am Acad Dermatol. 2014;70(4):670–78. Doi: 10.1016/j.jaad.2013.12.003.

50. Orlando G., Piraccini B.M., Starace M. The spectrum of fibrosing alopecias. JEADV. Clin Pract. 2022;1:186–95. Doi: 10.1002/jvc2.50.

51. Jerjen R., Pinczewski J., Sinclair R., Bhoyrul B. Clinicopathological characteristics and treatment outcomes of fibrosing alopecia in a pattern distribution: A retrospective cohort study. J Eur Acad Dermatol Venereol. 2021;35(1). Doi: 10.1111/jdv.17604.

52. Griggs J., Trueb R.M., Gavazzoni Dias M.F.R., et al. Fibrosing alopecia in a pattern distribution. J Am Acad Dermatol. 2021;85:1557–64.

53. Missio D., Dias M.R.G., Trueb R. Familial cicatricial alopecia: report of familial frontal fibrosing alopecia and fibrosing alopecia in a pattern distribution. Int J Trichol. 2017;9:130–34.

54. Ramanauskaite A., Trueb R. Facial papules in fibrosing alopecia in a pattern distribution (cicatricial pattern hair loss). Int J Trichol. 2015;7:119–22.

55. Liu Y.S., Jee S.H., Chan J.L. Hair transplantation for the treatment of lichen planopilaris and frontal fibrosing alopecia: A report of two cases. Australas J Dermatol. 2018;59(2):e118–22. Doi: 10.1111/ajd.12682.

56. Baquerizo Nole K.L., Nusbaum B., Pinto G.M., Miteva M. Lichen planopilaris in the androgenetic alopecia area: a pitfall for hair transplantation. Skin Appendage Disord. 2015;1(01):49–53.

57. Chiang Y.Z., Tosti A., Chaudhry I.H. Lichen planopilaris following hair transplantation and face-lift surgery. Br J Dermatol. 2012;166(03):666–370.

58. Alzolibani A.A., Kang H., Otberg N., et al. Pseudopelade of Brocq. Dermatol Ther. 2008;21:257–63.

59. Mirmirani P., Willey A., Headington J.T., et al. Primary cicatricial alopecia: histopathologic findings do not distinguish clinical variants. J Am Acad Dermatol 2005;52:637–43.

60. Yu M., Bell R.H., Ross E.K., et al. Lichen planopilaris and pseudopelade of Brocq involve distinct disease associated gene expression patterns by microarray. J Dermatol Sci. 2010;57:27–36.

61. Fabbri P., Amato L., Chiarini C., et al. Scarring alopecia in discoid lupus erythematosus: a clinical, histopathologic and immunopathologic study. Lupus. 2004;13:455–62.

62. Lopez-Tintos B.O., Garcia-Hidalgo L., Orozco-Topete R. Dermoscopy in active discoid lupus. Arch Dermatol. 2009;145:358.

63. Hordinsky M. Cicatricial alopecia: discoid lupus erythematosus. Dermatol Ther. 2008;21:245–8.

64. Desai K., Miteva M. Recent Insight on the Management of Lupus Erythematosus Alopecia. Clin Cosmet Investig Dermatol. 2021;14:333–47. Doi: 10.2147/CCID.S269288.

65. Trueb R.M. Involvement of scalp and nails in lupus erythematosus. Lupus. 2010;19(9):1078–86. Doi: 10.1177/0961203310373938.

66. Madura C., Vinay N., Kusuma M.R., et al. The assessment of Hair Transplantation Outcomes in Cicatricial Alopecia. Int J Trichol. 2020;12(4):164–67. Doi: 10.4103/ijt.ijt_52_19.

67. Kuhn A., Aberer E., Bata-Csorgo Z., et al. S2k guideline for treatment of cutaneous lupus erythematosus – guided by the European Dermatology Forum (EDF) in cooperation with the European Academy of Dermatology and Venereology (EADV). J Eur Acad Dermatol Venereol. 2017;31(3):389–404. Doi: 10.1111/ jdv.14053 37.

68. Garza-Mayers A.C., McClurkin M., Smith G.P. Review of treatment for discoid lupus erythematosus. Dermatol Ther. 2016;29 (4):274–83. Doi: 10.1111/dth.12358.

69. Lyakhovitsky A., Tzanani I., Gilboa S., et al. Changing spectrum of hair and scalp disorders over the last decade in a tertiary medical centre. J Eur Acad Dermatol. Venereol. 2023;37(1):184–93. Doi: 10.1111/jdv.18570.

70. Sarkis A., de Almeida R.F.C., Lemes L.R., et al. Folliculitis Decalvans in women: a retrospective multicenter study of 150 patients. J Eur Acad Dermatol Venereol. 2023 Aug 18. Doi: 10.1111/jdv.19434.

71. Moreno-Arrones O.M., Garcia-Hoz C., Del Campo R., et al. Folliculitis Decalvans Has a Heterogeneous Microbiological Signature and Impaired Immunological Response. Dermatol. 2023;239(3):454–61. Doi: 10.1159/000529301.

72. Otberg N., Kang H., Alzolibani A., et al. Folliculitis decalvans. Dermatol Ther. 2008;21:238–44.

73. Uchiyama M., Harada K., Tobita R., et al. Histopathologic and dermoscopic features of 42 cases of folliculitis decalvans: a case series. J Am Acad Dermatol. 2021;85(5):1185–89.

74. Egger A., Stojadinovic O., Miteva M. Folliculitis decalvans and lichen planopilaris phenotypic spectrum: a series of 7 new cases with focus on histopathology. Am J Dermatopathol. 2020;42(3):173–77.

75. Yang, L., Chen, J., Tong, X., et al. Photodynamic therapy should be considered for the treatment of folliculitis decalvans. Photodiagnos. Photodynam Ther. 2021;35:102356. Doi: 10.1016/j.pdpdt.2021.102356.

76. Tosti A., Torres F., Miteva M. Dermoscopy of Early Dissecting Cellulitis of the Scalp Simulates Alopecia Areata. Actas Dermo-Sifiliograficas (English Edition). 2013;104(1):92–3. Doi: 10.1016/j.adengl.2012.05.022.

77. May Lee M., Naldi L., Piraccini B.M., et al. Trichoscopy as a Tool to Evaluate Early Dissecting Cellulitis in Patients Affected by Hidradenitis Suppurativa: A Prospective Monocentric Observational Study. Skin Appendage Disord. 2023;9(4):275–79. Doi: 10.1159/000530630.

78. Nussbaum D., Desai S., Nelson K., et al. An Up-to-Date Approach to the Management of Dissecting Cellulitis. J. Drugs Dermatol. 2022;21(7):800–2. doi: 10.36849/JDD.0421.

79. Unger W., Unger R., Wesley C. The surgical treatment of cicatricial alopecia. Dermatol Ther. 2008;21(4):295–311. Doi: 10.1111/j.1529-8019.2008.00211.x.

80. Epstein J.S. Hair transplantation in women: treating female pattern baldness and repairing distortion and scarring from prior cosmetic surgery. Arch Facial Plast Surg. 2003;5(1):121–26. Doi: 10.1001/archfaci.5.1.121.

81. Ross E.K., Shapiro J. Management of hair loss. Dermatol Clin. 2005;23(2):227–43. Doi: 10.1016/j.det.2004.09.008.

82. Dahdah M.J., Iorizzo M. The Role of Hair Restoration Surgery in Primary Cicatricial Alopecia. Skin Appendage Disord. 2016;2(1–2):57–60. Doi: 10.1159/000448104.

83. Iorizzo M., Tosti A. Frontal Fibrosing Alopecia: An Update on Pathogenesis, Diagnosis, and Treatment. Am J Clin Dermatol. 2019;20(5 Suppl. 1):1–12. Doi: 10.1007/s40257-019-00424-y.

84. Singh S., Muthuvel K. Role of Hair Transplantation in Scarring Alopecia-To Do or Not to Do. Indian J Plast Surg. 2021;54(4):501–6. Doi: 10.1055/s-0041-1739246.

85. Ekelem C., Pham C., Atanaskova Mesinkovska N. A Systematic Review of the Outcome of Hair Transplantation in Primary Scarring Alopecia. Skin Appendage Disord. 2019;5(2):65–71. Doi: 10.1159/000492539.

86. Issa N.T., Tosti A. Trichoscopy for the Hair Transplant Surgeon-Assessing for Mimickers of Androgenetic Alopecia and Preoperative Evaluation of Donor Site Area. Indian J Plast Surg. 2021;54(4):393–98. Doi: 10.1055/s-0041-1739245.

Об авторах / Для корреспонденции

Автор для связи: Лариса Сергеевна Круглова, д.м.н., профессор, зав. кафедрой дерматовенерологии и косметологии, Центральная государственная медицинская академия УДП РФ, Москва, Россия; kruglovals@mail.ru

ORCID: 
Р.А. Раводин (R.A. Ravodin), https://orcid.org/0000-0002-0737-0317 
Е.А. Денисова (E.A. Denisova), https://orcid.org/0009-0000-4414-0417 
Л.С. Круглова (L.S. Kruglova), https://orcid.org/0000-0002-5044-5265 

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