Вагинальный микробиом и роль пробиотиков в поддержании женского здоровья
Вагинальный микробиом в последние годы стал предметом многих научных исследований во всем мире. Поддержание стабильности микробиоценоза влагалища признается важным фактором сохранения здоровья, причем не только на локальном уровне, но и в целом для женского организма. Пробиотики широко используются при лечении кишечных заболеваний, однако их влияние на женское репродуктивное здоровье до сих пор остается спорным. Лактобактерии – наиболее распространенный микроорганизм во влагалище, связанный с его слизистым барьером. Лактобактерии прикрепляются к эпителию влагалища и могут конкурентно противодействовать колонизации различных уловно-патогенных микроорганизмов. Факторы, продуцируемые лактобактериями, такие как бактериоцин и перекись водорода, могут подавлять рост условно-патогенных микроорганизмов и поддерживать низкий уровень pH во влагалище. Пробиотики играют важную роль в поддержании стабильности микробиома влагалища и повышении иммунной защиты организма женщины. Авторы обсуждают современную роль пробиотиков, представленных Lactobacillus, при различных гинекологических заболеваниях, а также их значение для поддержания женского здоровья.Хрянин А.А., Кнорринг Г.Ю.
Ключевые слова
влагалищный микробиом
бактериальный вагиноз
вульвовагинальный кандидоз
лактобактерии
пробиотики
женское здоровье
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Об авторах / Для корреспонденции
Автор для связи: Алексей Алексеевич Хрянин, д.м.н., профессор кафедры дерматовенерологии и косметологии, Новосибирский государственный медицинский университет, президент РОО «Ассоциация акушеров-гинекологов и дерматовенерологов», Новосибирск, Россия; khryanin@mail.ru
ORCID:
А.А. Хрянин (A.A. Khryanin), https://orcid.org/0000-0001-9248-8303
Г.Ю. Кнорринг (G.Yu. Knorring), https://orcid.org/0000-0003-4391-2889
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